The world is facing a number of challenges to ensure food security and nutrition, where water scarcity is major barrier because of global rise in freshwater demand, natural calamities such as droughts and floods, increased human consumption, overuse and wastage of water, climate change, overuse of aquifers and its consequent slow recharge. More crops per drop of water, namely crop water productivity (WP), could be a key strategy to address both challenges. This study assessed future wheat (Triticum aestivum L.) WP under changing climate along with adaptation strategies in northwestern Bangladesh. AquaCrop 5.0 model prior to calibration and validation was used coupled with Global Climate Models (GCMs) projections to simulate the yield and WP of wheat for the historical baseline (2000–2019), near future (2020–2039), mid-future (2040–2059), and far future (2080–2099) under Representative Concentration Pathway (RCP) 8.5 scenarios.